Oxidation of a tyrosine kinase inhibitor vandetanib by human cytochromes P450 and flavin monooxygenases in vitro and its effect of DNA adduct formation mediated by an anticancer drug ellipticine

FEBS OPEN BIO

INDRA, R.; POMPACH, P.; TAKÁCSOVÁ, P.; VÁVROVÁ, K.; HEGER, Z.; ADAM, V.; ECKSCHLAGER, T.; KOPEČKOVÁ, K.; STIBOROVÁ, M., 2018: Oxidation of a tyrosine kinase inhibitor vandetanib by human cytochromes P450 and flavin monooxygenases in vitro and its effect of DNA adduct formation mediated by an anticancer drug ellipticine . FEBS OPEN BIO 8, p. 350 - 1; FULL TEXT

Research Groups:

• Smart Nanodevices - Vojtěch Adam

CEITEC authors:

• Zbyněk Heger, Ph.D.
• Prof. Vojtěch Adam, Ph.D.