Dalibor Blažek, Ph.D.

Publications that are part of the Web of Science database, possibly also other publications chosen by authors.

2020

• Gajduskova, P; de los Mozos, IR; Rajecky, M; Hluchy, M; Ule, J; Blazek, D, 2020: CDK11 is required for transcription of replication-dependent histone genes. NATURE STRUCTURAL & MOLECULAR BIOLOGY , doi: 10.1038/s41594-020-0406-8
• Pilarova, K; Herudek, J; Blazek, D, 2020: CDK12: cellular functions and therapeutic potential of versatile player in cancer. NAR CANCER 2(1), doi: doi.org/10.1093/narcan/zcaa003

2019

• Manavalan, APC; Pilarova, K; Kluge, M; Bartholomeeusen, K; Rajecky, M; Oppelt, J; Khirsariya, P; Paruch, K; Krejci, L; Friedel, CC; Blazek, D, 2019: CDK12 controls G1/S progression by regulating RNAPII processivity at core DNA replication genes. EMBO REPORTS 20(9)

2016

• Greifenberg, AK; Honig, D; Pilarova, K; Duster, R; Bartholomeeusen, K; Bosken, CA; Anand, K; Blazek, D; Geyer, M, 2016: Structural and Functional Analysis of the Cdk13/Cyclin K Complex. CELL REPORTS 14(2), p. 320 - 331, doi: 10.1016/j.celrep.2015.12.025
• Blazek, D, 2016: TRANSCRIPTIONAL KINASES Caught by a sticky drug. NATURE CHEMICAL BIOLOGY 12(10), p. 765 - 766, doi: 10.1038/nchembio.2184
• Blazek, D, 2016: TRANSCRIPTIONAL KINASES Caught by a sticky drug. NATURE CHEMICAL BIOLOGY 12(10), p. 765 - 766, doi: 10.1038/nchembio.2184
• Blazek, D; Teque, F; Mackewicz, C; Peterlin, M; Levy, JA, 2016: The CD8+cell non-cytotoxic antiviral response affects RNA polymerase II-mediated human immunodeficiency virus transcription in infected CD4+cells. JOURNAL OF GENERAL VIROLOGY 97, p. 220 - 224, doi: 10.1099/jgv.0.000326

2015

• Ekumi, KM; Paculova, H; Pospichalova, V; Bosken, CA; Bryja, V; Geyer, M; Blazek, D; Barboric, M, 2015: Ovarian carcinoma CDK12 mutations misregulate DNA repair genes via deficient formation and function of the Cdk12/CycK complex. CLINICAL CANCER RESEARCH 21, doi: 10.1158/1557-3265.OVCASYMP14-AS21
• Ekumi, KM; Paculova, H; Lenasi, T; Pospichalova, V; Bosken, CA; Rybarikova, J; Bryja, V; Geyer, M; Blazek, D; Barboric, M, 2015: Ovarian carcinoma CDK12 mutations misregulate expression of DNA repair genes via deficient formation and function of the Cdk12/CycK complex. NUCLEIC ACIDS RESEARCH 43(5), p. 2575 - 2589, doi: 10.1093/nar/gkv101

2014

• Smerdova, L; Svobodova, J; Kabatkova, M; Kohoutek, J; Blazek, D; Machala, M; Vondracek, J, 2014: Upregulation of CYP1B1 expression by inflammatory cytokines is mediated by the p38 MAP kinase signal transduction pathway. CARCINOGENESIS 35(11), p. 2534 - 2543, doi: 10.1093/carcin/bgu190
• Bosken, CA; Farnung, L; Hintermair, C; Schachter, MM; Vogel-Bachmayr, K; Blazek, D; Anand, K; Fisher, RP; Eick, D; Geyer, M, 2014: The structure and substrate specificity of human Cdk12/Cyclin K. NATURE COMMUNICATIONS 5, doi: 10.1038/ncomms4505

2012

• Blazek, D, 2012: The cyclin K/Cdk12 complex An emerging new player in the maintenance of genome stability. CELL CYCLE 11(6), p. 1049 - 1050, doi: 10.4161/cc.11.6.19678
• Kohoutek, J; Blazek, D, 2012: Cyclin K goes with Cdk12 and Cdk13. CELL DIVISION 7, p. ´nestrankovano´ - , doi: 10.1186/1747-1028-7-12

2011

• Blazek, D; Kohoutek, J; Bartholomeeusen, K; Johansen, E; Hulinkova, P; Luo, ZP; Cimermancic, P; Ule, J; Peterlin, BM, 2011: The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes. GENES & DEVELOPMENT 25(20), p. 2158 - 2172, doi: 10.1101/gad.16962311

2009

• Kohoutek J., Li Q., Blazek D., Luo Z., Jiang H., Peterlin B.M., 2009: Cyclin T2 is essential for Mouse Embryogenesis. MOLECULAR AND CELLULAR BIOLOGY 29(12), p. 3280 - 3285

• DIANA panel pro testování selektivity inhibitorů klinicky relevantních kináz a jeho aplikace na trhu vývoje nových léčiv., , 2021 - 2024
• Charakterizace kinazové aktivity cyklin dependentní kinázy 11 (CDK11), Grantová agentura ČR, 2021 - 2023
• CDK12 controls G1/S progression by regulating RNAPII processivity at core DNA replication genes, Masarykova univerzita, 2019 - 2020
• Characterization of novel substrates and function for ovarian cancer-related cyclin-dependent kinase 12 (Cdk12) (GA17-13692S), Grantová agentura ČR, 2017 - 2019
• Charakterization of a new factor in regulation of transcription/mRNA processing of histone genes, Masarykova univerzita, 2018 - 2019
• Regulace genové exprese novým faktorem vázajícím mRNA (GA16-10930S), Grantová agentura ČR, 2016 - 2018
• Genome-wide analyses of a “non-canonical” cyclin-dependent kinase (CDK) (MUNI/E/0080/2017), Masarykova univerzita, 2017 - 2017
• Role Cdk12 a C-terminální domény RNA polymerázy II v transkripcně regulovaném procesu genomové nestability (GA14-09979S), Grantová agentura ČR, 2014 - 2016
• Funkční charakterizace unikátních zásobních ribonukleoproteinových částic v pylu (GAP501/11/1462), Grantová agentura ČR, 2011 - 2014
• The roles of Cdk12 in ovarian tumorigenesis, Nadace/fond - zahraniční, 2013 - 2014
• The roles of Cdk12 in ovarian tumorigenesis (MFR2013), Foundations - International - Marsha Rivkin Center, 2013 - 2014
• Nová izoforma cyklinu K je partnerem kinázy cdk12 regulující transkripci a alternativní sestřih u eukaryot (GAP305/11/1564), Grantová agentura ČR, 2011 - 2013
• Novel methylation of Hexim1 and cyclin composition of positive trancription elongation factor b (P-TEFb) regulate kinase activity of cdk9 (ME09047), MEYS - KONTAKT, 2009 - 2013
• Regulace a funkce P-TEFb komplexů, Jihomoravský kraj, 2010 - 2013
• Regulation and function of P-TEFb complexes (SRGA 454), South Moravian Region - SoMoPro, 2010 - 2013