Karol Pál, Ph.D.

Publications that are part of the Web of Science database, possibly also other publications chosen by authors.

2021

• van der Velden, VHJ; Bruggemann, M; Cazzaniga, G; Scheijen, B; Tops, B; Trka, J; Pal, K; Hanzelmann, S; Fazio, G; Songia, S; Langerak, AW; Darzentas, N, 2021: Potential and pitfalls of whole transcriptome-based immunogenetic marker identification in acute lymphoblastic leukemia; a EuroMRD and EuroClonality-NGS Working Group study. LEUKEMIA 35(3), p. 924 - 928, doi: 10.1038/s41375-021-01154-z
• Hynst, J; Navrkalova, V; Pal, K; Pospisilova, S, 2021: Bioinformatic strategies for the analysis of genomic aberrations detected by targeted NGS panels with clinical application. PEERJ 9, doi: 10.7717/peerj.10897
• Navrkalova, V; Plevova, K; Hynst, J; Pal, K; Mareckova, A; Reigl, T; Jelinkova, H; Vrzatova, Z; Starska, K; Pavlova, S; Panovska, A; Janikova, A; Doubek, M; Kotaskova, J; Pospisilova, S, 2021: LYmphoid NeXt-Generation Sequencing (LYNX) Panel A Comprehensive Capture-Based Sequencing Tool for the Analysis of Prognostic and Predictive Markers in Lymphoid Malignancies. JOURNAL OF MOLECULAR DIAGNOSTICS 23(8), p. 959 - 974, doi: 10.1016/j.jmoldx.2021.05.007

2020

• Polaskova, K; Merta, T; Martincekova, A; Zapletalova, D; Kyr, M; Mazanek, P; Krenova, Z; Mudry, P; Jezova, M; Tuma, J; Skotakova, J; Cervinkova, I; Valik, D; Zdrazilova-Dubska, L; Noskova, H; Pal, K; Slaby, O; Fabian, P; Kozakova, S; Neradil, J; Veselska, R; Kanderova, V; Hrusak, O; Freiberger, T; Klement, GL; Sterba, J, 2020: Comprehensive Molecular Profiling for Relapsed/Refractory Pediatric Burkitt Lymphomas-Retrospective Analysis of Three Real-Life Clinical Cases-Addressing Issues on Randomization and Customization at the Bedside. FRONTIERS IN ONCOLOGY 9, doi: 10.3389/fonc.2019.01531
• Vozdova, M; Kubickova, S; Pal, K; Frohlich, J; Fictum, P; Rubes, J, 2020: Recurrent gene mutations detected in canine mast cell tumours by next generation sequencing. VETERINARY AND COMPARATIVE ONCOLOGY 18(4), p. 509 - 518, doi: 10.1111/vco.12572
• Malcikova, J; Pavlova, S; Vonkova, B; Kotaskova, J; Radova, L; Plevova, K; Zenatova, M; Hynst, J; Dvorackova, B; Panovska, A; Brychtova, Y; Tichy, B; Navrkalova, V; Pal, K; Mayer, J; Doubek, M; Pospisilova, S, 2020: Minor-clone TP53 mutations in CLL patients entering first-line treatment: clonal evolution and clinical impact. LEUKEMIA & LYMPHOMA 61, p. 222 - 224
• Noskova, H; Kyr, M; Pal, K; Merta, T; Mudry, P; Polaskova, K; Ivkovic, TC; Adamcova, S; Hornakova, T; Jezova, M; Kren, L; Sterba, J; Slaby, O, 2020: Assessment of Tumor Mutational Burden in Pediatric Tumors by Real-Life Whole-Exome Sequencing and In Silico Simulation of Targeted Gene Panels: How the Choice of Method Could Affect the Clinical Decision?. CANCERS 12(1), doi: 10.3390/cancers12010230
• Gojo, J; Pavelka, Z; Zapletalova, D; Schmook, MT; Mayr, L; Madlener, S; Kyr, M; Vejmelkova, K; Smrcka, M; Czech, T; Dorfer, C; Skotakova, J; Azizi, AA; Chocholous, M; Reisinger, D; Lastovicka, D; Valik, D; Haberler, C; Peyrl, A; Noskova, H; Pal, K; Jezova, M; Veselska, R; Kozakova, S; Slaby, O; Slavc, I; Sterba, J, 2020: Personalized Treatment of H3K27M-Mutant Pediatric Diffuse Gliomas Provides Improved Therapeutic Opportunities. FRONTIERS IN ONCOLOGY 9, doi: 10.3389/fonc.2019.01436

2019

• Hernandez-Sanchez, M; Kotaskova, J; Rodriguez, AE; Radova, L; Tamborero, D; Abaigar, M; Plevova, K; Benito, R; Tom, N; Quijada-Alamo, M; Bikos, V; Martin, AA; Pal, K; de Coca, AG; Doubek, M; Lopez-Bigas, N; Hernandez-Rivas, JM; Pospisilova, S, 2019: CLL cells cumulate genetic aberrations prior to the first therapy even in outwardly inactive disease phase. LEUKEMIA 33(2), p. 518 - 522, doi: 10.1038/s41375-018-0255-1
• Doubkova, M; Kozubik, KS; Radova, L; Pesova, M; Trizuljak, J; Pal, K; Svobodova, K; Reblova, K; Svozilova, H; Vrzalova, Z; Pospisilova, S; Doubek, M, 2019: A novel germline mutation of the SFTPA1 gene in familial interstitial pneumonia. HUMAN GENOME VARIATION 6, doi: 10.1038/s41439-019-0044-z
• Mareckova, A; Malcikova, J; Tom, N; Pal, K; Radova, L; Salek, D; Janikova, A; Moulis, M; Smardova, J; Kren, L; Mayer, J; Trbusek, M, 2019: ATM and TP53 mutations show mutual exclusivity but distinct clinical impact in mantle cell lymphoma patients. LEUKEMIA & LYMPHOMA 60(6), p. 1420 - 1428, doi: 10.1080/10428194.2018.1542144
• Kozubik, KS; Trizuljak, J; Peova, M; Pal, K; Reblova, K; Radova, L; Pospiilova; Doubek, M, 2019: A novel germline mutation in GP1BA gene in family with hereditary macrothrombocytopenia. EUROPEAN JOURNAL OF HUMAN GENETICS 27, p. 208 - 208
• Taus, P; Plevova, K; Darzentas, N; Pal, K; Pospisilova, S, 2019: Identification of novel chronic lymphocytic leukemia subtypes using pathway mutation scores and consensus clustering. EUROPEAN JOURNAL OF HUMAN GENETICS 27, p. 1553 - 1554
• Knecht, H; Reigl, T; Kotrova, M; Appelt, F; Stewart, P; Bystry, V; Krejci, A; Grioni, A; Pal, K; Stranska, K; Plevova, K; Rijntjes, J; Songia, S; Svaton, M; Fronkova, E; Bartram, J; Scheijen, B; Herrmann, D; Garcia-Sanz, R; Hancock, J; Moppett, J; van Dongen, JJM; Cazzaniga, G; Davi, F; Groenen, PJTA; Hummel, M; Macintyre, EA; Stamatopoulos, K; Trka, J; Langerak, AW; Gonzalez, D; Pott, C; Bruggemann, M; Darzentas, N, 2019: Quality control and quantification in IG/TR next-generation sequencing marker identification: protocols and bioinformatic functionalities by EuroClonality-NGS. LEUKEMIA 33(9), p. 2254 - 2265, doi: 10.1038/s41375-019-0499-4
• Noskova, H; Adamcova, S; Knoflickova, D; Pal, K; Grioni, A; Hornakova, T; Merta, T; Mudry, P; Pavelka, Z; Vejmelkova, K; Sterba, J; Slaby, O, 2019: Comparison of whole exome sequencing and FoundationOne Heme sequencing panel as tools for precision oncology in paediatric patients with difficult-to-treat solid tumours. ANNALS OF ONCOLOGY 30, doi: 10.1093/annonc/mdz413.102

2018

• Melicharkova, K; Martincekova, A; Zapletalova, D; Kyr, M; Mazanek, P; Krenova, Z; Mudry, P; Tuma, J; Skotakova, J; Cervinkova, I; Valik, D; Zdrazilova-Dubska, L; Noskova, H; Pal, K; Slaby, O; Fabian, P; Kozakova, S; Neradil, J; Veselska, R; Kanderova, V; Hrusak, O; Freiberger, T; Klement, GL; Sterba, J, 2018: Customized, or randomized trials for relapsed refractory pediatric Burkitt lymphomas? A retrospective analysis of two clinical cases with comprehensive molecular profiling - possible explanation for different treatment outcomes after similar targeted therapies. BRITISH JOURNAL OF HAEMATOLOGY 182, p. 97 - 98
• Trizuljak, J; Kozubik, KS; Radova, L; Pesova, M; Pal, K; Reblova, K; Stehlikova, O; Smejkal, P; Zavrelova, J; Pacejka, M; Mayer, J; Pospisilova, S; Doubek, M, 2018: A novel germline mutation in GP1BA gene N-terminal domain in monoallelic Bernard-Soulier syndrome. PLATELETS 29(8), p. 827 - 833, doi: 10.1080/09537104.2018.1529300

2017

• Pal, K; Bystry, V; Reigl, T; Demko, M; Krejci, A; Touloumenidou, T; Stalika, E; Tichy, B; Ghia, P; Stamatopoulos, K; Pospisilova, S; Malcikova, J; Darzentas, N, 2017: GLASS: assisted and standardized assessment of gene variations from Sanger sequence trace data. BIOINFORMATICS 33(23), p. 3802 - 3804, doi: 10.1093/bioinformatics/btx423
• Malcikova, J; Kotaskova, J; Tom, N; Pal, K; Panovska, A; Brychtova, Y; Doubek, M; Pavlova, S; Pospisilova, S, 2017: Tracking low-burden TP53-mutated subclones during CLL treatment and remission using ROR1 separation. LEUKEMIA & LYMPHOMA 58, p. 162 - 163

2016

• Mareckov, A; Malcikova, J; Tom, N; Pal, K; Salek, D; Pospisilova, S; Trbusek, M, 2016: ATM GENE MUTATIONS REPRESENT A HALLMARK OF MANTLE CELL LYMPHOMA BUT DO NOT IMPACT PATIENTS´ SURVIVAL. HAEMATOLOGICA 101, p. 271 - 271

2015

• Tom, N; Malcikova, J; Radova, L; Kantorova, B; Pardy, F; Pavlova, S; Pal, K; Mraz, M; Tichy, B; Doubek, M; Brychtova, Y; Plevova, K; Mayer, J; Trbusek, M; Pospisilova, S, 2015: MUTATIONS IN THE TP53 GENE SHOW FEATURES OF SOMATIC HYPERMUTATION PROCESS WITH PROMINENT DIFFERENCE BETWEEN IGHV MUTATED AND UNMUTATED CHRONIC LYMPHOCYTIC LEUKEMIA. HAEMATOLOGICA 100, p. 224 - 225

• Creating synergies between research infrastructures to stimulate innovation in the cross-border region (ATCZ40), Ministerstvo pro místní rozvoj ČR, 2016 - 2020
• Národní centrum lékařské genomiky (LM2015091), Ministerstvo školství, mládeže a tělovýchovy ČR, 2016 - 2019
• NCLG - Národní centrum lékařské genomiky - modernizace infrastruktury a výzkum genetické variability populace (CZ.02.1.01/0.0/0.0/16_013/0001634), Ministerstvo školství, mládeže a tělovýchovy ČR, 2017 - 2019
• Expression and function of activation-induced cytidine deaminase splice variants in normal B cell physiology and chronic lymphocytic leukemia (3SGA5792), Jihomoravský kraj, 2013 - 2016
• Functional and structural changes of microRNAs in lymphoproliferative malignancies and their impact on prognosis and prediction of therapy response (NT11218), Ministry of Health - Ministry of Health´s Departmental Research and Development Programme III (2010-2015), 2010 - 2015
• NGS-PTL - Next Generation Sequencing platform for targeted Personalized Therapy of Leukemia (306242), Evropská unie, 2012 - 2015
• SuPReMMe - Podpora profesního růstu a mezinárodní integrace výzkumných týmů v oblasti molekulární medicíny (CZ.1.07/2.3.00/20.0045), Ministerstvo školství, mládeže a tělovýchovy ČR, 2011 - 2014
• Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies (MSM0021622430), Ministerstvo školství, mládeže a tělovýchovy ČR, 2007 - 2013
• Real-time PCR soupravy pro diagnostiku v onkologii (FR-TI2/254), Ministerstvo průmyslu a obchodu ČR, 2010 - 2013
• Involvement of nuclear HMGB proteins in sensitizing of human cells to anticancer drugs inhibiting DNA topoizomerases (GAP301/10/0590), Czech Science Foundation - Standard Grants, 2010 - 2012
• Analysis of changes in genome and its expression in chronic lymphocytic leukemia patients during the disease development (NS10439), Ministry of Health - Departmental Programme of Research and Development (2008-2011), 2009 - 2011