Contact
| Email: | , |
|---|---|
| Phone: | +420 54949 7807 |
| Research group: | Behavioural and Social Neuroscience - Milan Brázdil |
| Workplace: |
Job description
Research Interests: My research focuses on mapping the human brain in health and disease and particularly on biomarkers and underlying mechanisms of psychiatric diseases. This builds upon my expertise in population neuroscience, neuroimaging, and social neuroscience.
In my largest study so far, I focus on the neural-hormonal coupling during negative affect in patients with depression, bipolar disorder, and schizophrenia. I am verifying the presence of the neural and hormonal signatures of depressive symptomatology, which might possibly serve as early biomarkers, in a cohort of typically developing young adults. I am also interested in the comorbidity of psychiatric disorders with general medical disorders such as cardiovascular disease and obesity.
Thanks to the access to several European and North American cohort studies, I can take a life-course perspective and investigate the early origins of adult diseases. Starting with small-scale experimental studies focused on the sources of altered brain structure and function (e.g., studies of the impact of prenatal and pubertal androgens, studies of the role of menstrual cycle and the use oral contraception on brain function, studies on the effects of short term sleep deprivation on structural fluctuations in white matter), we can verify the results on samples from hundreds of individuals to improve our confidence in the findings. In particular, I am interested in prenatal and early postnatal exposures (stress, proinflammatory cytokines, androgens), development during adolescence, and their impact on health in adulthood.
Cooperation:
- University of Toronto (prof. Paus, prof. Pausova)
- Harvard Medical School (prof. Goldstein)
- Centre for Addiction and Mental Health (Dr. Nikolova)
Grants in the past:
- Biomarkers and underlying mechanisms of vulnerability to depression (FP7-PEOPLE-2013-IEF) - Marie Curie Fellow
- Sleep deprivation and structural fluctuations in white matter (funding from MŠMT and Child Mind Institute) - Local Coordinator
Bio: Dr. Klára Marečková is a Marie Curie Fellow in the Behavioral and Social Neuroscience (BeSoN) research group at the Central European Institute of Technology, Masaryk University. She received her M.Sc. in Cognitive Neuroscience and Neuroimaging at the University of Nottingham (UK) in 2008. In 2009, she moved to Canada to start her PhD at the Rotman Research Institute, Baycrest, under the supervision of prof. Tomas Paus. She defended her PhD thesis entitled Sex differences and the role of sex hormones on face development and face processing in 2013 and moved with her husband to their home town of Brno, Czech Republic, where she joined the BeSoN research group as a postdoctoral fellow. This position enabled her to focus on clinical neuroscience, develop a close collaboration with prof. Goldstein’s team at Harvard Medical School (US), and work with 50-year worth of data from New England Family Study. Her current work funded by Marie Curie grant (FP7-2013-IEF) enriches the European Longitudinal Study of Pregnancy and Childhood (ELSPAC) with neuroimaging (structural, functional and diffusion MRI), physiological, hormonal and behavioural data and studies Biomarkers and underlying mechanisms of vulnerability to depression (VULDE). Together with Prof. Paus, Klara also developed a collaboration between CEITEC MU and the Child Mind Institute in New York (US) and studies the effects of sleep deprivation on structural fluctuations in white matter. In addition, she serves as a reviewer for a number of peer reviewed journals (e.g. Brain Structure and Function, Neuroimage, Psychoneuroendocrinology, Hormones and Behavior), conferences (e.g. OHBM), and grant proposals (e.g. H2020).
24. Aug. 2020
Deprese matek ublíží i jejich dětem
Neurovědkyně Klára Marečková zkoumá, jaký má stres žen v těhotenství vliv na mozek jejich dospělých potomků. Před pěti lety navázala na práci svých…
1. Apr. 2020
Maternal Depression During Pregnancy Is Linked to Atypical Aging of the Offspring's Brain
Brain researcher Klara Mareckova from the Milan Brazdil’s Research Group discovered that maternal depressive symptoms during pregnancy are associated…
4. Jan. 2019
Neurovědkyně Klára Marečková pro MF DNES: Nevyspalý řidič je jako opilý
The article is only in Czech.
2. Nov. 2018
Klára Marečková: Stress at work? Maybe you just have to sleep well.
The article is only in Czech.
8. Nov. 2017
Klára Marečková: Náchylnost k depresím vzniká už v těhotenství
Stress in pregnancy may lead to more susceptibility of children to depression, Klára Marečková from CEITEC Masaryk University discovered. More…
Publications that are part of the Web of Science database, possibly also other publications chosen by authors.
2021
- Csajbok, Z; Kagstrom, A; Kareholt, I; Pawlowski, B; Mareckova, K; Cermakova, P, 2021: Sex differences in the association of childhood socioeconomic position and later-life depressive symptoms in Europe: the mediating effect of education. SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY , doi: 10.1007/s00127-020-02018-0
- Vackova, S; Kralik, M; Mareckova, K; Rackova, L; Quade, L; Sedlackova, L; Fojtik, P; Kucera, L, 2021: Human ´barcode´: Link between phosphate intensity changes in human enamel and light microscopy record of accentuated lines. MICROCHEMICAL JOURNAL 168, doi: 10.1016/j.microc.2021.106370
- Goldstein, JM; Cohen, JE; Mareckova, K; Holsen, L; Whitfield-Gabrieli, S; Gilman, SE; Buka, SL; Hornig, M, 2021: Impact of prenatal maternal cytokine exposure on sex differences in brain circuitry regulating stress in offspring 45 years later. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 118(15), doi: 10.1073/pnas.2014464118
2020
- Mareckova, K; Pacinkova, A; Klasnja, A; Shin, J; Andryskova, L; Stano-Kozubik, K; Pausova, Z; Brazdil, M; Paus, T, 2020: Epigenetic clock as a correlate of anxietyY. NEUROIMAGE-CLINICAL 28, doi: 10.1016/j.nicl.2020.102458
- Mareckova, K; Miles, A; Andryskova, L; Brazdil, M; Nikolova, Y, 2020: Temporally-Specific Effects of Maternal Perinatal Stress on Offspring Cortical Folding and Mood Dysregulation in Young Adulthood. BIOLOGICAL PSYCHIATRY 87(9), p. S132 - S132
- Garcia, RG; Mareckova, K; Holsen, LM; Cohen, JE; Whitfield-Gabrieli, S; Napadow, V; Barbieri, R; Goldstein, JM, 2020: Impact of sex and depressed mood on the central regulation of cardiac autonomic function. NEUROPSYCHOPHARMACOLOGY 45(8), p. 1280 - 1288, doi: 10.1038/s41386-020-0651-x
- Mareckova, K; Marecek, R; Andryskova, L; Brazdil, M; Nikolova, YS, 2020: Maternal Depressive Symptoms During Pregnancy and Brain Age in Young Adult Offspring: Findings from a Prenatal Birth Cohort. CEREBRAL CORTEX 30(7), p. 3991 - 3999, doi: 10.1093/cercor/bhaa014
- Mareckova, K; Miles, A; Andryskova, L; Brazdil, M; Nikolova, YS, 2020: Temporally and sex-specific effects of maternal perinatal stress on offspring cortical gyrification and mood in young adulthood. HUMAN BRAIN MAPPING 41(17), p. 4866 - 4875, doi: 10.1002/hbm.25163
2019
- Mareckova, K; Klasnja, A; Andryskova, L; Brazdil, M; Paus, T, 2019: Developmental origins of depression-related white matter properties: Findings from a prenatal birth cohort. HUMAN BRAIN MAPPING 40(4), p. 1155 - 1163, doi: 10.1002/hbm.24435
- Mareckova, K; Klasnja, A; Bencurova, P; Andryskova, L; Brazdil, M; Paus, T, 2019: Prenatal Stress, Mood, and Gray Matter Volume in Young Adulthood. CEREBRAL CORTEX 29(3), p. 1244 - 1250, doi: 10.1093/cercor/bhy030
2018
- Marečková, K.; Mareček, R.; Bencurova, P.; Klánová, J.; Dušek, L.; Brázdil, M., 2018: Perinatal stress and human hippocampal volume: Findings from typically developing young adults. SCIENTIFIC REPORTS , doi: 10.1038/s41598-018-23046-6
- Mareckova, K; Klasnja, A; Bencurova, P; Andyýskova, L; Brazdil, M; Paus, T, 2018: Prenatal stress, mood and gray matter volume in young adulthood. CEREBRAL CORTEX
2017
- Mareckova, K; Holsen, L; Admon, R; Whitfield-Gabrieli, S; Seidman, LJ; Buka, SL; Klibanski, A; Goldstein, JM, 2017: Neural - hormonal responses to negative affective stimuli: Impact of dysphoric mood and sex. JOURNAL OF AFFECTIVE DISORDERS 222, p. 88 - 97, doi: 10.1016/j.jad.2017.06.050
2016
- Mareckova, K; Holsen, LM; Admon, R; Makris, N; Seidman, L; Buka, S; Whitfield-Gabrieli, S; Goldstein, JM, 2016: Brain activity and connectivity in response to negative affective stimuli: Impact of dysphoric mood and sex across diagnoses. HUMAN BRAIN MAPPING 37(11), p. 3733 - 3744, doi: 10.1002/hbm.23271
2015
- Garcia, R; Mareckova, K; Fluegel, B; Holsen, L; Aizley, H; Remington, A; Whitfield-Gabrieli, S; Barbieri, R; Napadow, V; Goldstein, J, 2015: Central Modulation of Parasympathetic Response to Negative Affect is Disrupted in Major Depression: Impact of Sex. NEUROPSYCHOPHARMACOLOGY 40, p. S157 - S158
- Mareckova, K; Chakravarty, MM; Lawrence, C; Leonard, G; Perusse, D; Perron, M; Pike, BG; Richer, L; Veillette, S; Pausova, Z; Paus, T, 2015: Identifying craniofacial features associated with prenatal exposure to androgens and testing their relationship with brain development. BRAIN STRUCTURE & FUNCTION 220(6), p. 3233 - 3244, doi: 10.1007/s00429-014-0852-3
- Mareckova, K; Holsen, L; Admon, R; Whitfield-Gabrieli, S; Goldstein, J, 2015: Neural and Hormonal Responses to Negative Affective Stimuli: Impact of Sex and Depressed Mood. NEUROPSYCHOPHARMACOLOGY 40, p. S176 - S177
2014
- Mareckova, K; Holsen, L; Admon, R; Whitfield-Gabrieli, S; Goldstein, J, 2014: Mood Dysregulation and Stress Response Circuitry Deficits: Impact of Diagnosis, Mood State, and Sex. NEUROPSYCHOPHARMACOLOGY 39, p. S201 - S202
- Mareckova, K; Perrin, JS; Nawaz Khan, I; Lawrence, C; Dickie, E; McQuiggan, DA; Paus, T; IMAGEN Consortium, 2014: Hormonal contraceptives, menstrual cycle and brain response to faces. SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE 2(9), p. 191 - 200
2013
- Mareckova, K; Chakravarty, MM; Huang, M; Lawrence, C; Leonard, G; Perron, M; Pike, BG; Richer, L; Veillette, S; Pausova, Z; Paus, T, 2013: Does skull shape mediate the relationship between objective features and subjective impressions about the face?. NEUROIMAGE 79(79), p. 234 - 240, doi: 10.1016/j.neuroimage.2013.04.110
2012
- Tahmasebi, AM; Artiges, E; Banaschewski, T; Barker, GJ; Bruehl, R; Buchel, C; Conrod, PJ; Flor, H; Garavan, H; Gallinat, J; Heinz, A; Ittermann, B; Loth, E; Mareckova, K; Martinot, JL; Poline, JB; Rietschel, M; Smolka, MN; Strohle, A; Schumann, G; Paus, T, 2012: Creating probabilistic maps of the face network in the adolescent brain: A multicentre functional MRI study. HUMAN BRAIN MAPPING 33(4), p. 938 - 957, doi: 10.1002/hbm.21261
2011
- Mareckova, K; Weinbrand, Z; Chakravarty, M M; Lawrence, C; Aleong, R; Leonard, G; Perron, M; Pike, B G; Richer, L; Veillette, S; Pausova, Z; Paus, T, 2011: Testosterone-mediated sex differences in the face shape during adolescence: subjective impressions and objective features. HORMONES AND BEHAVIOR 5(60), p. 681 - 690, doi: 10.1016/j.yhbeh.2011.09.004
- Healthy Brain Ageing in Czechia over the life-course, , 2020 - 2023
- Economic Decision-Making: Hormonal Determinants and Ritualized Behavior, Masarykova univerzita, 2018 - 2021
- Developmental origins of depression-related white matter properties, Masarykova univerzita, 2018 - 2019
- Individuální rozdíly v diferenciaci mezi reprezentací sebe a druhých lidí (GA15-16738S), Grantová agentura ČR, 2015 - 2017
- Promoting stability and resilience in high-risk youth: AdoEHealth (MUNI/F/0055/2017), Masarykova univerzita, 2017 - 2017
- Biomarkers and underlying mechanisms of vulnerability to depression, Evropská unie, 2015 - 2017
- Understanding empathy using a second person neuroscience approach – a multimodal hyperscanning study combining fMRI and scalp EEG (7AMB15AT015), Ministerstvo školství, mládeže a tělovýchovy ČR, 2015 - 2016
- Zaměstnáním čerstvých absolventů doktorského studia k vědecké excelenci (CZ.1.07/2.3.00/30.0009), Ministerstvo školství, mládeže a tělovýchovy ČR, 2012 - 2015
- Optimalizace metodiky analýzy a hodnocení simultánního EEG-fMRI u pacientů s farmakorezistentní epilepsií (GAP304/11/1318), Grantová agentura ČR, 2011 - 2013