Liam Keegan, Ph.D.

Publications that are part of the Web of Science database, possibly also other publications chosen by authors.

2021

• Maroofian, R; Sedmík, J; Mazaheri, N; Scala, M; Zaki, MS; Keegan, LP; Azizimalamiri, R; Issa, M; Shariati, G; Sedaghat, A; Beetz, C; Bauer, P; Galehdari, H; O´Connell, MA; Houlden, H, 2021: Biallelic variants in ADARB1, encoding a dsRNA-specific adenosine deaminase, cause a severe developmental and epileptic encephalopathy. JOURNAL OF MEDICAL GENETICS , doi: 10.1136/jmedgenet-2020-107048
• Kurkowiak, M; Arcimowicz, L; Chrusciel, E; Urban-Wojciuk, Z; Papak, I; Keegan, L; O´Connell, M; Kowalski, J; Hupp, T; Marek-Trzonkowska, N, 2021: The effects of RNA editing in cancer tissue at different stages in carcinogenesis. RNA BIOLOGY , doi: 10.1080/15476286.2021.1877024

2020

• Piskacek, M; Havelka, M; Jendruchova, K; Knight, A; Keegan, LP, 2020: The evolution of the 9aaTAD domain in Sp2 proteins: inactivation with valines and intron reservoirs. CELLULAR AND MOLECULAR LIFE SCIENCES 77(9), p. 1793 - 1810, doi: 10.1007/s00018-019-03251-w
• Khan, A; Paro, S; McGurk, L; Sambrani, N; Hogg, MC; Brindle, J; Pennetta, G; Keegan, LP; O´Connell, MA, 2020: Membrane and synaptic defects leading to neurodegeneration in Adar mutant Drosophila are rescued by increased autophagy. BMC BIOLOGY 18(1), doi: 10.1186/s12915-020-0747-0
• Tan, TY; Sedmik, J; Fitzgerald, MP; Halevy, RS; Keegan, LP; Helbig, I; Basel-Salmon, L; Cohen, L; Straussberg, R; Chung, WK; Helal, M; Maroofian, R; Houlden, H; Juusola, J; Sadedin, S; Pais, L; Howell, KB; White, SM; Christodoulou, J; O´Connell, MA, 2020: Bi-allelic ADARB1 Variants Associated with Microcephaly, Intellectual Disability, and Seizures. AMERICAN JOURNAL OF HUMAN GENETICS 106(4), p. 467 - 483, doi: 10.1016/j.ajhg.2020.02.015

2019

• Wiatrek, DM; Candela, ME; Sedmik, JI; Oppelt, J; Keegan, LP; O´Connell, MA, 2019: Activation of innate immunity by mitochondrial dsRNA in mouse cells lacking p53 protein. RNA 25(6), p. 713 - 726, doi: 10.1261/rna.069625.118

2018

• O´Connell, M; Khan, A; Sambrani, N; Novakova, B; Keegan, L, 2018: Deciphering a novel role of ADAR in Drosophila development. FEBS OPEN BIO 8, p. 14 - 14

2017

• Bajad, P; Jantsch, MF; Keegan, L; O´Connell, M, 2017: A to I editing in disease is not fake news. RNA BIOLOGY 14(9), p. 1223 - 1231, doi: 10.1080/15476286.2017.1306173
• Keegan, L; Khan, A; Vukic, D; O´Connell, M, 2017: ADAR RNA editing below the backbone. RNA 23(9), p. 1317 - 1328, doi: 10.1261/rna.060921
• Tan, MH; Li, Q; Shanmugam, R; Piskol, R; Kohler, J; Young, AN; Liu, KI; Zhang, R; Amaswami, GR; Ariyoshi, K; Gupte, A; Keegan, LP; George, CX; Amu, AR; Huang, N; Pollina, EA; Leeman, DS; Ustighi, AR; Goh, YPS; Hawla, AC; Del Sal, G; Peltz, G; Runet, AB; Onrad, DFC; Samuel, CE; O´Connell, MA; Walkley, CR; Nishikura, K; Li, JB, 2017: Dynamic landscape and regulation of RNA editing in mammals. NATURE 550(7675), p. 249 - +, doi: 10.1038/nature24041

2015

• Mannion, N; Arieti, F; Gallo, A; Keegan, LP; O´Connell, MA, 2015: New Insights into the Biological Role of Mammalian ADARs; the RNA Editing Proteins. BIOMOLECULES 5(4), p. 2338 - 2362, doi: 10.3390/biom5042338
• M. A. O’Connell; N. Mannion; L.P. Keegan, 2015: The Epitranscriptome and Innate Immunity. PLOS GENETICS 12(11), doi: 10.1371/journal.pgen.1005687

2014

• Mannion, NM; Greenwood, SM; Young, R; Cox, S; Brindle, J; Read, D; Nellaker, C; Vesely, C; Ponting, CP; McLaughlin, PJ; Jantsch, MF; Dorin, J; Adams, IR; Scadden, ADJ; Ohman, M; Keegan, LP; O´Connell, MA, 2014: The RNA-Editing Enzyme ADAR1 Controls Innate Immune Responses to RNA. CELL REPORTS 9(4), p. 1482 - 1494, doi: 10.1016/j.celrep.2014.10.041

2013

• Ramaswami, G; Zhang, R; Piskol, R; Keegan, LP; Deng, P; O´Connell, MA; Li, JB, 2013: Identifying RNA editing sites using RNA sequencing data alone. NATURE METHODS 10(2), p. 128 - 132, doi: 10.1038/NMETH.2330

2012

• Rice, GI; Kasher, PR; Forte, GMA; Mannion, NM; Greenwood, SM; Szynkiewicz, M; Dickerson, JE; Bhaskar, SS; Zampini, M; Briggs, TA; Jenkinson, EM; Bacino, CA; Battini, R; Bertini, E; Brogan, PA; Brueton, LA; Carpanelli, M; De Laet, C; de Lonlay, P; del Toro; Keegan, LP; O´Connell, MA; Lovell, SC; Crow, YJ, 2012: Mutations in ADAR1 cause Aicardi-Goutieres syndrome associated with a type I interferon signature. NATURE GENETICS 44(11), p. 1243 - 1248, doi: 10.1038/ng.2414

2011

• Marcucci, R; Brindle, J; Paro, S; Casadio, A; Hempel, S; Morrice, N; Bisso, A; Keegan, LP; Del Sal, G; O´Connell, MA, 2011: Pin1 and WWP2 regulate GluR2 Q/R site RNA editing by ADAR2 with opposing effects. EMBO JOURNAL 30(20), p. 4211 - 4222, doi: 10.1038/emboj.2011.303

2010

• Galeano, F; Leroy, A; Rossetti, C; Gromova, I; Gautier, P; Keegan, LP; Massimi, L; Di Rocco, C; O´Connell, MA; Gallo, A, 2010: Human BLCAP transcript: new editing events in normal and cancerous tissues. INTERNATIONAL JOURNAL OF CANCER 127(1), p. 127 - 137, doi: 10.1002/ijc.25022

2009

• Heale, BSE; Keegan, LP; McGurk, L; Michlewski, G; Brindle, J; Stanton, CM; Caceres, JF; O´Connell, MA, 2009: Editing independent effects of ADARs on the miRNA/siRNA pathways. EMBO JOURNAL 28(20), p. 3145 - 3156, doi: 10.1038/sj.emboj.2009.244

• A mouse genetic model to study the control of interferon and inflammation, Grantová agentura ČR, 2019 - 2022
• Generation of stable cell lines for the screening of inhibitors of the ADAR enzymes, Masarykova univerzita, 2020 - 2021