Marek Mráz, Ph.D.

Publications that are part of the Web of Science database, possibly also other publications chosen by authors.

2021

• Sharma, S; Pavlasova, GM; Seda, V; Cerna, KA; Vojackova, E; Filip, D; Ondrisova, L; Sandova, V; Kostalova, L; Zeni, PF; Borsky, M; Oppelt, J; Liskova, K; Kren, L; Janikova, A; Pospisilova, S; Fernandes, SM; Shehata, M; Rassenti, LZ; Jaeger, U; Doubek, M; Davids, MS; Brown, JR; Mayer, J; Kipps, TJ; Mraz, M, 2021: miR-29 modulates CD40 signaling in chronic lymphocytic leukemia by targeting TRAF4: an axis affected by BCR inhibitors. BLOOD 137(18), p. 2481 - 2494, doi: 10.1182/blood.2020005627

2020

• Lobello, C; Tichy, B; Bystry, V; Radova, L; Filip, D; Mraz, M; Montes-Mojarro, IA; Prokoph, N; Larose, H; Liang, HC; Sharma, GG; Mologni, L; Belada, D; Kamaradova, K; Fend, F; Gambacorti-Passerini, C; Merkel, O; Turner, SD; Janikova, A; Pospisilova, S, 2020: STAT3 and TP53 mutations associate with poor prognosis in anaplastic large cell lymphoma. LEUKEMIA , doi: 10.1038/s41375-020-01093-1
• Ondrisova, L; Mraz, M, 2020: Genetic and Non-Genetic Mechanisms of Resistance to BCR Signaling Inhibitors in B Cell Malignancies. FRONTIERS IN ONCOLOGY 10, doi: 10.3389/fonc.2020.591577
• Filip, D; Mraz, M, 2020: The role of MYC in the transformation and aggressiveness of ?indolent? B-cell malignancies. LEUKEMIA & LYMPHOMA , doi: 10.1080/10428194.2019.1675877
• Pavlasova, G; Mraz, M, 2020: The regulation and function of CD20: an ´enigma´ of B-cell biology and targeted therapy. HAEMATOLOGICA 105(6), p. 1494 - 1506, doi: 10.3324/haematol.2019.243543

2019

• Peskova, L; Cerna, K; Oppelt, J; Mraz, M; Barta, T, 2019: Oct4-mediated reprogramming induces embryonic-like microRNA expression signatures in human fibroblasts. SCIENTIFIC REPORTS 9, doi: 10.1038/s41598-019-52294-3
• Boudny, M; Zemanova, J; Khirsariya, P; Borsky, M; Verner, J; Cerna, J; Oltova, A; Seda, V; Mraz, M; Jaros, J; Jaskova, Z; Spunarova, M; Brychtova, Y; Soucek, K; Drapela, S; Kasparkova, M; Mayer, J; Paruch, K; Trbusek, M, 2019: Novel CHK1 inhibitor MU380 exhibits significant single-agent activity in TP53-mutated chronic lymphocytic leukemia cells. HAEMATOLOGICA 104(12), p. 2443 - 2455, doi: 10.3324/haematol.2018.203430
• Mraz, M; Pospisilova, S, 2019: Detection of a deletion at 22q11 locus involving ZNF280A/ZNF280B/PRAME/GGTLC2 in B-cell malignancies: simply a consequence of an immunoglobulin lambda light chain rearrangement. BRITISH JOURNAL OF HAEMATOLOGY 186(4), p. E91 - E94, doi: 10.1111/bjh.15922
• Spunarova, M; Tom, N; Pavlova, S; Mraz, M; Brychtova, Y; Doubek, M; Panovska, A; Francova, HS; Brzobohata, A; Pospisilova, S; Mayer, J; Trbusek, M, 2019: Impact of gene mutations and chromosomal aberrations on progression-free survival in chronic lymphocytic leukemia patients treated with front-line chemoimmunotherapy: Clinical practice experience. LEUKEMIA RESEARCH 81, p. 75 - 81, doi: 10.1016/j.leukres.2019.04.015
• Cerna, K; Oppelt, J; Musilova, K; Seda, V;Pavlasova, K; Radova, L; Arigoni, M; Calogero, RA; Benes, V; Tbusek, M; Brychtova, Y; Doubek, M; Mayer, J; Pospisilova, S; Mraz, M, 2019: MicroRNA miR-34a downregulates FOXP1 during DNA damage response to limit BCR signalling in chronic lymphocytic leukaemia B cells. LEUKEMIA

2018

• Devan, J; Janikova, A; Mraz, M, 2018: New concepts in follicular lymphoma biology: From BCL2 to epigenetic regulators and non-coding RNAs. SEMINARS IN ONCOLOGY 45(2019-06-05T00:00:00.000), p. 291 - 302, doi: 10.1053/j.seminoncol.2018.07.005
• Stamatopoulos, B; Smith, T; Crompot, E; Pieters, K; Clifford, R; Mraz, M; Robbe, P; Burns, A; Timbs, A; Bruce, D; Hillmen, P; Meuleman, N; Mineur, P; Firescu, R; Maerevoet, M; De Wilde, V; Efira, A; Philippe, J; Verhasselt, B; Offner, F; Sims, D; Heger, A; Dreau, H; Schuh, A, 2018: The Light Chain IgLV3-21 Defines a New Poor Prognostic Subgroup in Chronic Lymphocytic Leukemia: Results of a Multicenter Study. CLINICAL CANCER RESEARCH 24(20), p. 5048 - 5057, doi: 10.1158/1078-0432.CCR-18-0133
• Musilova, K; Devan, J; Cerna, K; Seda, V; Pavlasova, G; Sharma, S; Oppelt, J; Pytlik, R; Prochazka, V; Prouzova, Z; Trbusek, M; Zlamalikova, L; Liskova, K; Kruzova, L; Jarosova, M; Mareckova, A; Kornauth, C; Simonitsch-Klupp, I; Schiefer, A; Merkel, O; Mocikova, H; Burda, P; Polakova, K; Kren, L; Mayer, J; Zent, CS; Trneny, M; Evans, A; Janikova, A; Mraz, M, 2018: miR-150 downregulation contributes to the high-grade transformation of follicular lymphoma by upregulating FOXP1 levels. BLOOD
• Pavlasova, G; Borsky, M; Svobodova, V; Oppelt, J; Cerna, K; Novotna, J; Seda, V; Fojtova, M; Fajkus, J; Brychtova, Y; Doubek, M; Pospisilova, S; Mayer, J; Mraz, M, 2018: Rituximab primarily targets an intra-clonal BCR signaling proficient CLL subpopulation characterized by high CD20 levels. LEUKEMIA 32(9), p. 2028 - 2031, doi: 10.1038/s41375-018-0211-0

2017

• Mraz, M; Cerna, K; Oppelt, J; Seda, V; Musilova, K; Pavlasova, G; Mayer, J; Pospisilova, S, 2017: MicroRNA induced by DNA damage response regulates the expression of FOXP1 and therapy response in CLL. LEUKEMIA & LYMPHOMA 58, p. 73 - 74
• Pavlasova, G; Borsky, M; Svobodova, V; Musilova, K; Cerna, K; Seda, V; Osickova, J; Brychtova, Y; Doubek, M; Pospisilova, S; Mayer, J; Mraz, M, 2017: BCR SIGNALLING PROFICIENT CHRONIC LYMPHOCYTIC LEUKAEMIA B CELLS ARE PRONE TO RITUXIMAB MEDIATED ELIMINATION IN VIVO. HAEMATOLOGICA 102, p. 412 - 412
• Jarosova, M; Hruba, M; Oltova, A; Plevova, K; Kruzova, L; Kriegova, E; Fillerova, R; Koritakova, E; Doubek, M; Lysak, D; Prochazka, V; Mraz, M; Indrak, K; Papajik, T, 2017: Chromosome 6q deletion correlates with poor prognosis and low relative expression of FOXO3 in chronic lymphocytic leukemia patients. AMERICAN JOURNAL OF HEMATOLOGY 92(10), p. E604 - E607, doi: 10.1002/ajh.24852
• Pavlasova, G; Musilova, K; Seda, V; Cerna, K; Vojackova, E; Svobodova, V; Mraz, M, 2017: The identification of combinatorial therapeutic approaches with BCR inhibitors in B cell malignancies. MOLECULAR CANCER THERAPEUTICS 16(10)
• Bencurova, P; Baloun, J; Musilova, K; Radova, L; Tichy, B; Pail, M; Zeman, M; Brichtova, E; Hermanova, M; Pospisilova, S; Mraz, M; Brazdil, M, 2017: MicroRNA and mesial temporal lobe epilepsy with hippocampal sclerosis: Whole miRNome profiling of human hippocampus. EPILEPSIA 58(10), p. 1782 - 1793, doi: 10.1111/epi.13870

2016

• Pavlasova, G; Borsky, M; Seda, V; Cerna, K; Osickova, J; Doubek, M; Mayer, J; Calogero, R; Trbusek, M; Pospisilova, S; Davids, MS; Kipps, TJ; Brown, JR; Mraz, M, 2016: Ibrutinib inhibits CD20 upregulation on CLL B cells mediated by the CXCR4/SDF-1 axis. BLOOD 128(12), p. 1609 - 1613, doi: 10.1182/blood-2016-04-709519
• Pavlasova, G; Borsky, M; Seda, V; Cerna, K; Osickova, J; Doubek, M; Mayer, J; Calogero, R; Pospisilova, S; Davids, M; Brown, J; Mraz, M, 2016: IBRUTINIB INHIBITS CD20 UP-REGULATION ON CLL B CELLS MEDIATED BY THE CXCR4/SDF-1 AXIS. HAEMATOLOGICA 101, p. 47 - 47

2015

• Tom, N; Malcikova, J; Radova, L; Kantorova, B; Pardy, F; Pavlova, S; Pal, K; Mraz, M; Tichy, B; Doubek, M; Brychtova, Y; Plevova, K; Mayer, J; Trbusek, M; Pospisilova, S, 2015: MUTATIONS IN THE TP53 GENE SHOW FEATURES OF SOMATIC HYPERMUTATION PROCESS WITH PROMINENT DIFFERENCE BETWEEN IGHV MUTATED AND UNMUTATED CHRONIC LYMPHOCYTIC LEUKEMIA. HAEMATOLOGICA 100, p. 224 - 225
• Pavlasova, G; Seda, V; Borsky, M; Cerna, K; Osickova, J; Mayer, J; Pospisilova, S; Davids, MS; Brown, JR; Mraz, M, 2015: Microenvironmental Interactions up-Regulate CD20 Expression in CLL B Cells through the CXCR4/SDF-1 Axis: Implications for CD20-Targeting Antibodies and the Use of BCR-Inhibitors in Combination. BLOOD 126(23)
• Pavlasova, G; Borsky, M; Seda, V; Cerna, K; Osickova, J; Mayer, J; Pospisilova, S; Davids, M; Brown, J; Mraz, M, 2015: Microenvironmental interactions up-regulate CD20 expression in CLL B cells, but confer resistance to rituximab. LEUKEMIA & LYMPHOMA 56, p. 76 - 77
• Dolezalova D; Mraz M; Hampl A, 2015: miRNA in Embryonic Stem Cells. IN MICRORNA IN REGENERATIVE MEDICINE (BOOK CHAPTER)
• Malcikova, J; Stano-Kozubik, K; Tichy, B; Kantorova, B; Pavlova, S; Tom, N; Radova, L; Smardova, J; Pardy, F; Doubek, M; Brychtova, Y; Mraz, M; Plevova, K; Diviskova, E; Oltova, A; Mayer, J; Pospisilova, S; Trbusek, M, 2015: Detailed analysis of therapy-driven clonal evolution of TP53 mutations in chronic lymphocytic leukemia. LEUKEMIA 29(4), p. 877 - 885, doi: 10.1038/leu.2014.297
• Musilova, K; Mraz, M, 2015: MicroRNAs in B-cell lymphomas: how a complex biology gets more complex. LEUKEMIA 29(5), p. 1004 - 1017, doi: 10.1038/leu.2014.351
• Seda, V; Mraz, M, 2015: B-cell receptor signalling and its crosstalk with other pathways in normal and malignant cells. EUROPEAN JOURNAL OF HAEMATOLOGY 94(3), p. 193 - 205, doi: 10.1111/ejh.12427

2014

• Mraz, M; Chen, LG; Rassenti, LZ; Ghia, EM; Li, HY; Jepsen, K; Smith, EN; Messer, K; Frazer, KA; Kipps, TJ, 2014: miR-150 influences B-cell receptor signaling in chronic lymphocytic leukemia by regulating expression of GAB1 and FOXP1. BLOOD 124(1), p. 84 - 95, doi: 10.1182/blood-2013-09-527234
• Cui, B; Chen, LG; Zhang, SP; Mraz, M; Fecteau, JF; Yu, J; Ghia, EM; Zhang, L; Bao, L; Rassenti, LZ; Messer, K; Calin, GA; Croce, CM; Kipps, TJ, 2014: MicroRNA-155 influences B-cell receptor signaling and associates with aggressive disease in chronic lymphocytic leukemia. BLOOD 124(4), p. 546 - 554, doi: 10.1182/blood-2014-03-559690
• te Raa, GD; Malcikova, J; Mraz, M; Trbusek, M; Le Garff-Tavernier, M; Merle-Beral, H; Greil, R; Merkel, O; Pospisilova, S; Lin, K; Pettitt, AR; Stankovic, T; van Oers, MH; Eldering, E; Stilgenbauer, S; Zenz, T; Kater, AP, 2014: Assessment of TP53 functionality in chronic lymphocytic leukaemia by different assays; an ERIC-wide approach. BRITISH JOURNAL OF HAEMATOLOGY 167(4), p. 565 - 569, doi: 10.1111/bjh.13006
• Cerna, K; Oppelt, J; Radova, L; Pardy, F; Tom, N; Musilova, K; Malcikova, J; Plevova, K; Tichy, B; Brychtova, Y; Doubek, M; Trbusek, M; Koca, J; Calogero, R; Mayer, J; Pospisilova, S; Mraz, M, 2014: BIOLOGICAL AND CLINICAL RELEVANCE OF MIRNAS INDUCED IN CHRONIC LYMPHOCYTIC LEUKEMIA (CLL) CELLS DURING ADMINISTRATION OF THERAPY IN VIVO AND IN VITRO. HAEMATOLOGICA 99, p. 41 - 42
• Kminkova, J; Mraz, M; Zaprazna, K; Navrkalova, V; Tichy, B; Plevova, K; Malcikova, J; Cerna, K; Rausch, T; Benes, V; Brychtova, Y; Doubek, M; Mayer, J; Pospisilova, S, 2014: Identification of novel sequence variations in microRNAs in chronic lymphocytic leukemia. CARCINOGENESIS 35(5), p. 992 - 1002, doi: 10.1093/carcin/bgt396

2013

• Mraz, M; Kipps, TJ, 2013: MicroRNAs and B cell receptor signaling in chronic lymphocytic leukemia. LEUKEMIA & LYMPHOMA 54(8), p. 1836 - 1839, doi: 10.3109/10428194.2013.796055
• Navrkalova, V; Sebejova, L; Zemanova, J; Kminkova, J; Kubesova, B; Malcikova, J; Mraz, M; Smardova, J; Pavlova, S; Doubek, M; Brychtova, Y; Potesil, D; Nemethova, V; Mayer, J; Pospisilova, S; Trbusek, M, 2013: ATM mutations uniformly lead to ATM dysfunction in chronic lymphocytic leukemia: application of functional test using doxorubicin. HAEMATOLOGICA 98(7), p. 1124 - 1131, doi: 10.3324/haematol.2012.081620
• Mraz, M; Kozubik, KS; Plevova, K; Musilova, K; Tichy, B; Borsky, M; Kuglik, P; Doubek, M; Brychtova, Y; Mayer, J; Pospisilova, S, 2013: The origin of deletion 22q11 in chronic lymphocytic leukemia is related to the rearrangement of immunoglobulin lambda light chain locus. LEUKEMIA RESEARCH 37(7), p. 802 - 808, doi: 10.1016/j.leukres.2013.03.018

2012

• te Raa, D; Malcikova, J; Mraz, M; Pospisilova, S; Le Garff-Tavernier, M; Merle-Beral, H; Stankovic, T; van Oers, MHJ; Eldering, E; Stilgenbauer, S; Zenz, T; Kater, AP, 2012: Assessment of p53 Functionality in Chronic Lymphocytic Leukemia by Different Assays; An Eric-Wide Approach.. BLOOD 120(21)
• Touskova, V; Trachta, P; Kavalkova, P; Drapalova, J; Haluzikova, D; Mraz, M; Lacinova, Z; Marek, J; Haluzik, M, 2012: Serum concentrations and tissue expression of components of insulin-like growth factor-axis in females with type 2 diabetes mellitus and obesity: The influence of very-low-calorie diet. MOLECULAR AND CELLULAR ENDOCRINOLOGY 361(42036), p. 172 - 178, doi: 10.1016/j.mce.2012.04.005
• Dolezalova, D; Mraz, M; Barta, T; Plevova, K; Vinarsky, V; Holubcova, Z; Jaros, J; Dvorak, P; Pospisilova, S; Hampl, A, 2012: MicroRNAs Regulate p21(Waf1/Cip1) Protein Expression and the DNA Damage Response in Human Embryonic Stem Cells. STEM CELLS 30(7), p. 1362 - 1372, doi: 10.1002/stem.1108
• Doubek, M; Trbusek, M; Malcikova, J; Brychtova, Y; Smardova, J; Lochmanova, J; Panovska, A; Francova, HS; Mraz, M; Tichy, B; Sebejova, L; Navrkalova, V; Plevova, K; Kuglik, P; Mayer, J; Pospisilova, S, 2012: Specific p53 mutations do not impact results of alemtuzumab therapy among patients with chronic lymphocytic leukemia. LEUKEMIA & LYMPHOMA 53(9), p. 1817 - 1819, doi: 10.3109/10428194.2012.658794
• Verner, J; Kabathova, J; Tomancova, A; Pavlova, S; Tichy, B; Mraz, M; Brychtova, Y; Krejci, M; Zdrahal, Z; Trbusek, M; Volejnikova, J; Sedlacek, P; Doubek, M; Mayer, J; Pospisilova, S, 2012: Gene expression profiling of acute graft-vs-host disease after hematopoietic stem cell transplantation. EXPERIMENTAL HEMATOLOGY 40(11), p. 899 - 905, doi: 10.1016/j.exphem.2012.06.011
• Mraz, M; Pospisilova, S, 2012: MicroRNAs in chronic lymphocytic leukemia: from causality to associations and back. EXPERT REVIEW OF HEMATOLOGY 5(6), p. 579 - 581, doi: 10.1586/EHM.12.54
• Mraz, M; Dolezalova, D; Plevova, K; Kozubik, KS; Mayerova, V; Cerna, K; Musilova, K; Tichy, B; Pavlova, S; Borsky, M; Verner, J; Doubek, M; Brychtova, Y; Trbusek, M; Hampl, A; Mayer, J; Pospisilova, S, 2012: MicroRNA-650 expression is influenced by immunoglobulin gene rearrangement and affects the biology of chronic lymphocytic leukemia. BLOOD 119(9), p. 2110 - 2113, doi: 10.1182/blood-2011-11-394874
• MRAZ, M.;M. TRBUSEK;D. DOLEZALOVA;J. MALCIKOVA;J. SUPIKOVA;K. STANO KOZUBIK;B. KANTOROVA;J. MAYER;S. POSPISILOVA., 2012: Identifikace patogeneticky vyznamnych mutaci u chronicke lymfocytarni leukemie pomoci ´sekvenovani nove generace´. TRANSFUZE A HEMATOLOGIE DNES 18, p. 72 - 75

2011

• Mraz, M; Plevova, K; Dolezalova, D; Stano-Kozubik, K; Mayerova, V; Cerna, K; Musilova, K; Pavlova, S; Tichy, B; Lochmanova, J; Doubek, M; Brychtova, Y; Trbusek, M; Hampl, A; Mayer, J; Pospisilova, S, 2011: The Regulation, Targets and Clinical Relevance of Microrna Mir-650 in Chronic Lymphocytic Leukemia (CLL). BLOOD 118(21), p. 1655 - 1656
• Lochmanova, J; Mraz, M; Navrkalova, V; Dvorakova, B; Tichy, B; Plevova, K; Sebejova, L; Malcikova, J; Pavlova, S; Benes, V; Rausch, T; Brychtova, Y; Doubek, M; Trbusek, M; Mayer, J; Pospisilova, S, 2011: Mutational Analysis of Mir-29 Family Members in Chronic Lymphocytic Leukemia. BLOOD 118(21), p. 772 - 772
• Vargova, K; Curik, N; Burda, P; Basova, P; Kulvait, V; Pospisil, V; Savvulidi, F; Kokavec, J; Necas, E; Berkova, A; Obrtlikova, P; Karban, J; Mraz, M; Pospisilova, S; Mayer, J; Trneny, M; Zavadil, J; Stopka, T, 2011: MYB transcriptionally regulates the miR-155 host gene in chronic lymphocytic leukemia. BLOOD 117(14), p. 3816 - 3825, doi: 10.1182/blood-2010-05-285064
• Trbusek, M; Smardova, J; Malcikova, J; Sebejova, L; Dobes, P; Svitakova, M; Vranova, V; Mraz, M; Francova, HS; Doubek, M; Brychtova, Y; Kuglik, P; Pospisilova, S; Mayer, J, 2011: Missense Mutations Located in Structural p53 DNA-Binding Motifs Are Associated With Extremely Poor Survival in Chronic Lymphocytic Leukemia. JOURNAL OF CLINICAL ONCOLOGY 29(19), p. 2703 - 2708, doi: 10.1200/JCO.2011.34.7872
• Mraz, M; Zent, CS; Church, AK; Jelinek, DF; Wu, XS; Pospisilova, S; Ansell, SM; Novak, AJ; Kay, NE; Witzig, TE; Nowakowski, GS, 2011: Bone marrow stromal cells protect lymphoma B-cells from rituximab-induced apoptosis and targeting integrin alpha-4-beta-1 (VLA-4) with natalizumab can overcome this resistance. BRITISH JOURNAL OF HAEMATOLOGY 155(1), p. 53 - 64, doi: 10.1111/j.1365-2141.2011.08794.x

2010

• Mraz, Marek; Zent, Clive S.; Church, Amy K.; Baig, Nisar A.; Jelinek, Diane F.; Wu, Xiaosheng; Pospisilova, Sarka; Ansell, Stephen M.; Novak, Anne J.; Witzig, Thomas E.; Nowakowski, Grzegorz S., 2010: Interactions with the Microenvironment Protect Lymphoma B-Cells From Rituximab Induced Apoptosis and Could Represent a Therapeutic Target.. BLOOD 116(21), p. 1284 - 1284

2009

• Mraz, Marek; Malinova, Karla; Pavlova, Sarka; Tichy, Boris; Kozubik, Katerina Stano; Malcikova, Jitka; Borsky, Marek; Verner, Jan; Doubek, Michael; Brychtova, Yvona; Trbusek, Martin; Mayer, Jiri; Pospisilova, Sarka, 2009: Detail Characterization of 22q11 Deletion and Mir-650 Role in CLL Patients. BLOOD 114(22), p. 507 - 508
• MRAZ, M., MALINOVA, K., KOTASKOVA, J., PAVLOVA, S., TICHY, B., MALCIKOVA, J., STANO-KOZUBIK, K., SMARDOVA, J., BRYCHTOVA, Y., DOUBEK, M., TRBUSEK, M., MAYER, J., POSPISILOVA, S., 2009: miR-34a, miR-29c and miR-17-5p are downregulated in CLL patients with TP53 abnormalities. LEUKEMIA 23(6), p. 1159 - 1163

• Signaling propensity in the microenvironment of B cell chronic lymphocytic leukemia, Evropská unie, 2019 - 2024
• Alliance for Life Sciences: From Strategies to Actions in Central and Eastern Europe, , 2021 - 2024
• ÚLOHA MICRORNA A JEJICH CÍLOVÝCH MOLEKUL V TRANSFORMACI FOLIKULÁRNÍHO LYMFOMU A AGRESIVITĚ CHRONICKÉ LYMFOCYTÁRNÍ LEUKÉMIE, Ministry of Health of the CR, 2018 - 2021
• Coding and Non-coding RNA Networks that Regulate B Cell Receptor Signalling: Implications for Combinatorial Therapy (MUNI/H/0865/2016), Masarykova univerzita, 2017 - 2019
• The role of microRNAs in the biology of B cell leukemias and lymphomas, Jihomoravský kraj, 2014 - 2016
• Funkční a strukturní změny microRNA u lymfoproliferativních malignit a jejich vliv na prognózu onemocnění a predikci léčebné odpovědi, Ministry of Health of the CR, 2010 - 2015