Prof. Marek Svoboda, Ph.D.

Publications that are part of the Web of Science database, possibly also other publications chosen by authors.

2021

• Koleckova, M; Ehrmann, J; Bouchal, J; Janikova, M; Brisudova, A; Srovnal, J; Staffova, K; Svoboda, M; Slaby, O; Radova, L; Vomackova, K; Melichar, B; Veverkova, L; Kolar, Z, 2021: Epithelial to mesenchymal transition and microRNA expression are associated with spindle and apocrine cell morphology in triple-negative breast cancer. SCIENTIFIC REPORTS 11(1), doi: 10.1038/s41598-021-84350-2

2020

• Seles, M; Hutterer, GC; Fosselteder, J; Svoboda, M; Resel, M; Barth, DA; Pichler, R; Bauernhofer, T; Zigeuner, RE; Pummer, K; Slaby, O; Klec, C; Pichler, M, 2020: Long Non-Coding RNA PANTR1 is Associated with Poor Prognosis and Influences Angiogenesis and Apoptosis in Clear-Cell Renal Cell Cancer. CANCERS 12(5), doi: 10.3390/cancers12051200

2018

• Sklenicka, V; Kucharova, K; Svoboda, M, 2018: Creep behaviour and microstructure evolution of advanced creep-resistant 9%Cr martensitic steels under cyclic thermal loading. KOVOVE MATERIALY-METALLIC MATERIALS 56(1), p. 1 - 13, doi: 10.4149/km_2018_1_1
• Vychytilova-Faltejskova, P; Stitkovcova, K; Radova, L; Sachlova, M; Kosarova, Z; Slaba, K; Kala, Z; Svoboda, M; Kiss, I; Vyzula, R; Cho, WC; Slaby, O, 2018: Circulating PIWI-Interacting RNAs piR-5937 and piR-28876 Are Promising Diagnostic Biomarkers of Colon Cancer. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION 27(9), p. 1019 - 1028, doi: 10.1158/1055-9965.EPI-18-0318

2017

• Vychytilova-Faltejskova, P; Merhautova, J; Machackova, T; Gutierrez-Garcia, I; Garcia-Solano, J; Radova, L; Brchnelova, D; Slaba, K; Svoboda, M; Halamkova, J; Demlova, R; Kiss, I; Vyzula, R; Conesa-Zamora, P; Slaby, O, 2017: MiR-215-5p is a tumor suppressor in colorectal cancer targeting EGFR ligand epiregulin and its transcriptional inducer HOXB9. ONCOGENESIS 6, doi: 10.1038/s41389-017-0006-6

2016

• Iliev, R; Fedorko, M; Machackova, T; Mlcochova, H; Svoboda, M; Pacik, D; Dolezel, J; Stanik, M; Slaby, O, 2016: Expression Levels of PIWI-interacting RNA, piR-823, Are Deregulated in Tumor Tissue, Blood Serum and Urine of Patients with Renal Cell Carcinoma. ANTICANCER RESEARCH 36(12), p. 6419 - 6423, doi: 10.21873/anticanres.11239
• Iliev, R; Kleinova, R; Juracek, J; Dolezel, J; Ozanova, Z; Fedorko, M; Pacik, D; Svoboda, M; Stanik, M; Slaby, O, 2016: Overexpression of long non-coding RNA TUG1 predicts poor prognosis and promotes cancer cell proliferation and migration in high-grade muscle-invasive bladder cancer. TUMOR BIOLOGY 37(10), p. 13385 - 13390, doi: 10.1007/s13277-016-5177-9
• Machackova, T; Mlcochova, H; Stanik, M; Dolezel, J; Fedorko, M; Pacik, D; Poprach, A; Svoboda, M; Slaby, O, 2016: MiR-429 is linked to metastasis and poor prognosis in renal cell carcinoma by affecting epithelial-mesenchymal transition. TUMOR BIOLOGY 37(11), p. 14653 - 14658, doi: 10.1007/s13277-016-5310-9
• Vychytilova-Faltejskova, P; Pesta, M; Radova, L; Liska, V; Daum, O; Kala, Z; Svoboda, M; Kiss, I; Slaby, O, 2016: Genome-wide microRNA Expression Profiling in Primary Tumors and Matched Liver Metastasis of Patients with Colorectal Cancer. CANCER GENOMICS & PROTEOMICS 13(4), p. 311 - 316
• Kiss, I; Mlcochova, J; Bortlicek, Z; Poprach, A; Drabek, J; Vychytilova-Faltejskova, P; Svoboda, M; Buchler, T; Batko, S; Ryska, A; Hajduch, M; Slaby, O, 2016: Efficacy and Toxicity of Panitumumab After Progression on Cetuximab and Predictive Value of MiR-31-5p in Metastatic Wild-type KRAS Colorectal Cancer Patients. ANTICANCER RESEARCH 36(9), p. 4955 - 4959, doi: 10.21873/anticanres.11063
• Vychytilova-Faltejskova, P; Radova, L; Sachlova, M; Kosarova, Z; Slaba, K; Fabian, P; Grolich, T; Prochazka, V; Kala, Z; Svoboda, M; Kiss, I; Vyzula, R; Slaby, O, 2016: Serum-based microRNA signatures in early diagnosis and prognosis prediction of colon cancer. CARCINOGENESIS 37(10), p. 941 - 950, doi: 10.1093/carcin/bgw078
• Mlcochova, H; Machackova, T; Rabien, A; Radova, L; Fabian, P; Iliev, R; Slaba, K; Poprach, A; Kilic, E; Stanik, M; Redova-Lojova, M; Svoboda, M; Dolezel, J; Vyzula, R; Jung, K; Slaby, O, 2016: Epithelial-mesenchymal transition-associated microRNA/mRNA signature is linked to metastasis and prognosis in clear-cell renal cell carcinoma. SCIENTIFIC REPORTS 6, doi: 10.1038/srep31852

2013

• BILEK, O.;S. TUCEK;K. VESELY;P. FABIAN;B. ROBESOVA;D. ADAMKOVA KRAKOROVA;R. LAKOMY;M. SVOBODA;A. JURECKOVA;J. HALAMKOVA;J. KRALOVA;L. SIKULINCOVA;J. PODHOREC;J. TOMASEK;I. KISS;R. VYZULA., 2013: Maligni melanom leceny intenzivni chemoterapii, podobnost histologickeho obrazu maligniho melanomu a nadoru mekkych tkani, kazuistika pacientky. KLINICKA ONKOLOGIE 26, p. 42 - 46
• Hrstka, R; Brychtova, V; Fabian, P; Vojtesek, B; Svoboda, M, 2013: AGR2 Predicts Tamoxifen Resistance in Postmenopausal Breast Cancer Patients. DISEASE MARKERS , p. 207 - 212, doi: 10.1155/2013/761537

2012

• Poprach, A; Bortlicek, Z; Buchler, T; Melichar, B; Lakomy, R; Vyzula, R; Brabec, P; Svoboda, M; Dusek, L; Gregor, J, 2012: Patients with advanced and metastatic renal cell carcinoma treated with targeted therapy in the Czech Republic: twenty cancer centres, six agents, one database. MEDICAL ONCOLOGY 29(5), p. 3314 - 3320, doi: 10.1007/s12032-012-0286-9
• Svoboda, M; Poprach, A; Dobes, S; Kiss, I; Vyzula, R, 2012: Cardiac Toxicity of Targeted Therapies Used in the Treatment for Solid Tumours: A Review. CARDIOVASCULAR TOXICOLOGY 12(3), p. 191 - 207, doi: 10.1007/s12012-012-9164-0

2011

• Lakomy, R; Sana, J; Hankeova, S; Fadrus, P; Kren, L; Lzicarova, E; Svoboda, M; Dolezelova, H; Smrcka, M; Vyzula, R; Michalek, J; Hajduch, M; Slaby, O, 2011: MiR-195, miR-196b, miR-181c, miR-21 expression levels and O-6-methylguanine-DNA methyltransferase methylation status are associated with clinical outcome in glioblastoma patients. CANCER SCIENCE 102(12), p. 2186 - 2190, doi: 10.1111/j.1349-7006.2011.02092.x

• Komplexní genomové profilování u pacientek s karcinomem ovaria léčených platinovými deriváty: identifikace prediktivních biomarkerů a ověření využitelnosti precizní onkologie, , 2021 - 2024
• Molecular classification of renal cell carcinoma based on long noncoding RNAs expression and its implication for diagnosis, prognosis and therapy, Ministry of Health of the CR, 2018 - 2021
• Diagnostické a prognostické dopady korelace miRNA expresního profilu s morfologickou heterogenitou u ´triple-negative´ karcinomů prsu (16-31997A), Ministry of Health of the CR, 2016 - 2020
• Využití tkáňových/cirkulujících mikroRNA pro predikci léčebné odpovědi a zpřesnění restagingu karcinomu rekta po neoadjuvantní léčbě (16-31765A), Ministry of Health of the CR, 2016 - 2019
• Expression and function of activation-induced cytidine deaminase splice variants in normal B cell physiology and chronic lymphocytic leukemia (3SGA5792), Jihomoravský kraj, 2013 - 2016
• MicroRNA analysis in glioblastoma stem cells: prediction of therapy response and identification of new therapeutic targets in glioblastoma patients (NT/13514), Ministry of Health - Ministry of Health´s Departmental Research and Development Programme III (2010-2015), 2012 - 2015
• Vytvoření diagnostické sady cirkulujících mikroRNA pro neinvazivní časnou diagnostiku a sledování pacientů s kolorektálním karcinomem, Ministry of Health of the CR, 2012 - 2015
• Complex characterization of molecular genetic changes in glioblastoma multiforme and its relapses, and evaluation of their possible significance in oncologic therapy and therapy effect (NT/13581), Ministry of Health - Ministry of Health´s Departmental Research and Development Programme III (2010-2015), 2012 - 2015
• Functional and structural changes of microRNAs in lymphoproliferative malignancies and their impact on prognosis and prediction of therapy response (NT11218), Ministry of Health - Ministry of Health´s Departmental Research and Development Programme III (2010-2015), 2010 - 2015
• Studium mikroRNA a genů asociovaných s procesem epiteliálně-mezenchymální tranzice jako potenciálních markerů pro predikci rizika a časný záchyt metastazování u pacientů s renálním karcinomem (NT13547-4/2012), Ministry of Health of the CR, 2012 - 2015
• Development of diagnostic panel of circulating microRNAs for non-invasive early diagnostics and follow-up of colorectal cancer patients (NT/13549), Ministry of Health - Ministry of Health´s Departmental Research and Development Programme III (2010-2015), 2012 - 2015
• Analysis of EGFR signalling and microRNA expression profiles in prediction of response to anti-EGFR (NT/13860), Ministry of Health - Ministry of Health´s Departmental Research and Development Programme III (2010-2015), 2012 - 2015
• NGS-PTL - Next Generation Sequencing platform for targeted Personalized Therapy of Leukemia (306242), Evropská unie, 2012 - 2015
• Development of microRNA diagnostic panel for identification Barret esophagus patients at high-risk of progression to adenocarcinoma (NT13585), Ministry of Health - Ministry of Health´s Departmental Research and Development Programme III (2010-2015), 2012 - 2014
• SuPReMMe - Podpora profesního růstu a mezinárodní integrace výzkumných týmů v oblasti molekulární medicíny (CZ.1.07/2.3.00/20.0045), Ministerstvo školství, mládeže a tělovýchovy ČR, 2011 - 2014
• Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies (MSM0021622430), Ministerstvo školství, mládeže a tělovýchovy ČR, 2007 - 2013
• Identification and functional characterization of microRNAs with predictive significance in patients with glioblastoma (NT/11214), Ministry of Health - Ministry of Health´s Departmental Research and Development Programme III (2010-2015), 2010 - 2013
• Real-time PCR soupravy pro diagnostiku v onkologii (FR-TI2/254), Ministerstvo průmyslu a obchodu ČR, 2010 - 2013
• Involvement of nuclear HMGB proteins in sensitizing of human cells to anticancer drugs inhibiting DNA topoizomerases (GAP301/10/0590), Czech Science Foundation - Standard Grants, 2010 - 2012
• Analysis of changes in genome and its expression in chronic lymphocytic leukemia patients during the disease development (NS10439), Ministry of Health - Departmental Programme of Research and Development (2008-2011), 2009 - 2011