Contact
| Email: | |
|---|---|
| Phone: | +420 54949 7022, +420 777 926 655 |
| Research group: | Centre for Structural Biology |
| Workplace: |
Masarykova univerzita - CEITEC Masarykova Univerzita
|
Job description
Coordinator of Research Infrastructure of CEITEC MU and Chair of the Czech Infrastructure for Integrative Structural Biology (CIISB)
Affiliation:
National Centre for Biomolecular Research, Faculty of Science and Central European Institute of Technology, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic
Position Title:
Faculty of Science, Masaryk University Brno - Professor of Physical Chemistry
Central European Institute of Technology, Masaryk University Brno, Coordinator of Research Infrastructures and Chair of the Czech Infrastructure for Integrative Structural Biology (CIISB)
Education/Degrees:
| Institution and Location | Degree | Years | Scientific Field |
| University of J.E. Purkyně, Brno | Mgr. | 1974 | Chemistry |
| University of J.E. Purkyně, Brno | RNDr. | 1975 | Physical Chemistry |
| Technical University, Brno | CSc. (Ph.D.) | 1984 | Applied Physics |
| Technical University, Brno | Doc. (Ass. Prof.) | 1992 | Physical Chemistry |
| Institute of Chemical Technology, Prague | DrSc. (D.Sc.) | 1996 | Physical Chemistry |
| Masaryk University, Brno | Professor | 1997 | Physical Chemistry |
Professional Positions:
| 1976–1984: | Research Associate, Dept. of Radiofrequency Spectroscopy, Institute of Scientific Instruments, Czechoslovak Academy of Sciences, Brno, Czechoslovakia. |
| 1984–1986: | Research Scientist, Dept. of Radiofrequency Spectroscopy, Institute of Scientific Instruments, Czechoslovak Academy of Sciences, Brno, Czechoslovakia. |
| 1986–1987: | Visiting Fellow, Laboratory of Chemical Physics, NIDDK, National Institutes of Health, Bethesda, MD., USA. |
| 1987–1992: | Principal Research Scientist, Dept. of Radiofrequency Spectroscopy, Institute of Scientific Instruments, Czechoslovak Academy of Sciences, Brno, Czechoslovakia. |
| 1992 – 1995: | Visiting Scientist, Marion Merrell Dow Research Institute, Biophysics Core Facility, Strasbourg, France. |
| 1989 to 1999: | Visiting Scholar, Department of Chemistry and Biochemistry, University of California, USA, Los Angeles, Laboratory of Prof. Juli Feigon. |
| 1995 to present: | Professor of Physical Chemistry, Masaryk University Brno, Czech Republic |
| 1996 to 2000: | Deputy Head of National Centre for Biomolecular Research, Masaryk University, Brno, Czech Republic |
| 2000 to present: | Deputy Head of National Centre for Biomolecular Research, Masaryk University, Brno, Czech Republic |
| 2010 to 2015: | Coordinator of Structural Biology Programme, Central European Institute of Technology, Head of Structural Biology Center, Masaryk University, and Group Leader of RG Biomolecular NMR Spectroscopy |
| 2016 - to present: | Coordinator of Research Infrastructure of CEITEC MU and Chair of the Czech Infrastructure for Integrative Structural Biology (CIISB) |
Awards and Other Professional Activities:
| 1995-1998: | Chemistry Board, Grant Agency of Academy of Science of the Czech Republic |
| 1993 to 1998: | Council Member of ISMAR (International Society of Magnetic Resonance) |
| 1996 to 1999: | Scientific Council of the Institute of Scientific Instruments, Czech Academy of Sciences, Brno |
| 1999 to 2004: | Scientific Council of Masaryk University Brno |
| 1999 to 2006: | Scientific Council of Faculty of Science, Masaryk University Brno |
| 2000 to 2002: | Scientific Council of Charles University Prague |
| 2001 | Award of the Learned Society of the Czech Republic |
| 2002 | Member of the Learned Society of the Czech Republic |
| 1997 to 2010: | Editorial Board, Journal of Magnetic Resonance |
| 2003 to present: | Editorial Board, Central European Journal of Chemistry |
| 2005 to present: | Editorial Board, Journal of Biomolecular NMR |
| 2007 to 2011: | Council of the Institute of Biophysics, Czech Academy of Sciences, Brno |
| 2011: | Jan Marcus Marci Medal of Jan Marcus Marci Spectroscopic Society |
| 2012: | Vladimír Hanuš and Peter Sedmera Prize of Jan Marcus Marci Spectroscopic Society |
| 2014: | Masaryk University Rector's Award for Scientific Lifetime Achievements |
| 2014 to present: | Member of the EUROMAR Board of Trustees |
Research Interests:
Experimental methods of multi-dimensional NMR spectroscopy and structural biology, dynamics and theoretical description of spin system evolution, multiple resonance NMR technique for structural studies of proteins and nucleic acids by NMR spectroscopy and molecular dynamics, ab initio quantum chemistry calculations, structure and dynamics of biomolecular systems
Publications: 145 papers in peer reviewed international journals, more than 9103 citations, h-index=39 (as of February 6, 2018), ResearcherID: F-9118-2011; ); more than 10 200 citations, h-index=41 (as of February 6, 2018 on Google Scholar, user profile Vladimir Sklenar)
19. Aug. 2020
CEITEC Awarded By the Mayor of Brno for Help During the Pandemic
Solidarity and immediacy. This was, among other things, highlighted by the mayor of the city of Brno, Markéta Vaňková, at the closing ceremony of the…
26. Mar. 2020
CEITEC Offers Its Laboratories For Coronavirus Research Free Of Charge
Time is the most important factor in the fight against coronavirus SARS-CoV-2. Large research infrastructures in the Czech Republic, such as CEITEC…
2. Mar. 2020
Doctoral Students from CEITEC Masaryk University Presented Their Research Results at CEITEC PhD Conference
On 10 February 2020 at the CEITEC PhD Conference, the scientific community and the general public learned about the scientific directions that…
21. Jan. 2020
CEITEC Masaryk University Received a Subsidy of 565 Million CZK for Innovation of Instrumentation
Investice do přístrojového vybavení pomohou prodloužit jeho životnost a především udržet špičkovou úroveň výzkumu na MUNI i v celém Česku.…
17. Dec. 2019
EU invests 10 million euro in unlocking technologies for key research in structural biology
Press release, 17. 12. 2019; To enable researchers from European institutes to extend innovative structural biology research, the EU has invested 10…
25. Jan. 2011
An international conference for 180 scientists from all over the world is being held in Brno
180 scientists from the whole of Europe, USA, Israel and Russia arrived at the Continental hotel in Brno. The main subject of the congress AUM 2011…
Publications that are part of the Web of Science database, possibly also other publications chosen by authors.
2018
- Sicorello, A; Kelly, G; Oregioni, A; Novacek, J; Sklenar, V; Pastore, A, 2018: The Structural Properties in Solution of the Intrinsically Mixed Folded Protein Ataxin-3. BIOPHYSICAL JOURNAL 115(1), p. 59 - 71, doi: 10.1016/j.bpj.2018.05.029
2017
- Srb, P; Novacek, J; Kaderavek, P; Rabatinova, A; Krasny, L; Zidkova, J; Bobalova, J; Sklenar, V; Zidek, L, 2017: Triple resonance NMR relaxation experiments for studies of intrinsically disordered proteins. JOURNAL OF BIOMOLECULAR NMR 69(3), p. 133 - 146, doi: 10.1007/s10858-017-0138-1
2016
- Kaderavek, P; Zapletal, V; Fiala, R; Srb, P; Padrta, P; Precechtelova, JP; Soltesova, M; Kowalewski, J; Widmalm, G; Chmelik, J; Sklenar, V; Zidek, L, 2016: Spectral density mapping at multiple magnetic fields suitable for C-13 NMR relaxation studies. JOURNAL OF MAGNETIC RESONANCE 266, p. 23 - 40, doi: 10.1016/j.jmr.2016.02.016
- Vavrinska, A; Zelinka, J; Sebera, J; Sychrovsky, V; Fiala, R; Boelens, R; Sklenar, V; Trantirek, L, 2016: Impact of nucleic acid self-alignment in a strong magnetic field on the interpretation of indirect spin-spin interactions (vol 64, pg 53, 2016). JOURNAL OF BIOMOLECULAR NMR 65(1), p. 49 - 49, doi: 10.1007/s10858-016-0034-0
- Vavrinska, A; Zelinka, J; Sebera, J; Sychrovsky, V; Fiala, R; Boelens, R; Sklenar, V; Trantirek, L, 2016: Impact of nucleic acid self-alignment in a strong magnetic field on the interpretation of indirect spin-spin interactions. JOURNAL OF BIOMOLECULAR NMR 64(1), p. 53 - 62, doi: 10.1007/s10858-015-0005-x
- Perczel, A; Atanasov, AG; Sklenar, V; Novacek, J; Papouskova, V; Kaderavek, P; Zidek, L; Kozlowski, H; Watly, J; Hecel, A; Kolkowska, P; Koca, J; Svobodova-Varekova, R; Pravda, L; Sehnal, D; Horsky, V; Geidl, S; Enriz, RD; Matejka, P; Jenistova, A; Dendisova, M; Kokaislova, A; Weissig, V; Olsen, M; Coffey, A; Ajuebor, J; Keary, R; Sanz-Gaitero, M; Raaij, MJ; McAuliffe, O; Waltenberger, B; Mocan, A; Smejkal, K; Heis, EH; Diederich, M; Musiol, R; Kosmrlj, J; Polanski, J; Jampilek, J, 2016: The Eighth Central European Conference ´´Chemistry towards Biology´´: Snapshot. MOLECULES 21(10), doi: 10.3390/molecules21101381
2015
- Yurenko, YP; Novotny, J; Sklenar, V; Marek, R, 2015: Substituting CF2 for O4 ´ in Components of Nucleic Acids: Towards Systems with Reduced Propensity to Form Abasic Lesions. CHEMISTRY-A EUROPEAN JOURNAL 21(49), p. 17933 - 17943, doi: 10.1002/chem.201502977
- MacRaild, CA; Zachrdla, M; Andrew, D; Krishnarjuna, B; Novacek, J; Zidek, L; Sklenar, V; Richards, JS; Beeson, JG; Anders, RF; Norton, RS, 2015: Conformational Dynamics and Antigenicity in the Disordered Malaria Antigen Merozoite Surface Protein 2. PLOS ONE 10(3), doi: 10.1371/journal.pone.0119899
2014
- Vymetal, J; Bathula, SR; Cerny, J; Chaloupkova, R; Zidek, L; Sklenar, V; Vondrasek, J, 2014: Retro operation on the Trp-cage miniprotein sequence produces an unstructured molecule capable of folding similar to the original only upon 2,2,2-trifluoroethanol addition. PROTEIN ENGINEERING DESIGN & SELECTION 27(12), p. 463 - 472, doi: 10.1093/protein/gzu046
- Hritz, J; Byeon, IJL; Krzysiak, T; Martinez, A; Sklenar, V; Gronenborn, AM, 2014: Dissection of Binding between a Phosphorylated Tyrosine Hydroxylase Peptide and 14-3-3 zeta: A Complex Story Elucidated by NMR. BIOPHYSICAL JOURNAL 107(9), p. 2185 - 2194, doi: 10.1016/j.bpj.2014.08.039
- Yurenko, YP; Novotny, J; Mitoraj, MP; Sklenar, V; Michalak, A; Marek, R, 2014: Nucleic Acid Quadruplexes Based on 8-Halo-9-deazaxanthines: Energetics and Noncovalent Interactions in Quadruplex Stems. JOURNAL OF CHEMICAL THEORY AND COMPUTATION 10(12), p. 5353 - 5365, doi: 10.1021/ct5007554
- Yurenko, YP; Novotny, J; Sklenar, V; Marek, R, 2014: Exploring non-covalent interactions in guanine- and xanthine-based model DNA quadruplex structures: a comprehensive quantum chemical approach. PHYSICAL CHEMISTRY CHEMICAL PHYSICS 16(5), p. 2072 - 2084, doi: 10.1039/c3cp53875c
- Kaderavek, P; Zapletal, V; Rabatinova, A; Krasny, L; Sklenar, V; Zidek, L, 2014: Spectral density mapping protocols for analysis of molecular motions in disordered proteins. JOURNAL OF BIOMOLECULAR NMR 58(3), p. 193 - 207, doi: 10.1007/s10858-014-9816-4
- Novacek, J; Zidek, L; Sklenar, V, 2014: Toward optimal-resolution NMR of intrinsically disordered proteins. JOURNAL OF MAGNETIC RESONANCE 241, p. 41 - 52, doi: 10.1016/j.jmr.2013.12.008
- Babinsky, M; Fiala, R; Kejnovska, I; Bednarova, K; Marek, R; Sagi, J; Sklenar, V; Vorlickova, M, 2014: Loss of loop adenines alters human telomere d[AG(3)(TTAG(3))(3)] quadruplex folding. NUCLEIC ACIDS RESEARCH 42(22), p. 14031 - 14041, doi: 10.1093/nar/gku1245
2013
- Emmer, J; Vavrinska, A; Sychrovsky, V; Benda, L; Kriz, Z; Koca, J; Boelens, R; Sklenar, V; Trantirek, L, 2013: Influence of the O-phosphorylation of serine, threonine and tyrosine in proteins on the amidic N-15 chemical shielding anisotropy tensors. JOURNAL OF BIOMOLECULAR NMR 55(1), p. 59 - 70, doi: 10.1007/s10858-012-9686-6
- Kadam, SS; Maier, L; Solomek, T; Necas, M; Smejkal, K; Dostal, J; Sklenar, V; Marek, R, 2013: Structure and NMR properties of 6-substituted-5,6-dihydrobenzo[c]phenanthridine alkaloids. JOURNAL OF PHYSICAL ORGANIC CHEMISTRY 26(10), p. 814 - 821, doi: 10.1002/poc.3175
- Rabatinova, A; Sanderova, H; Matejckova, JJ; Korelusova, J; Sojka, L; Barvik, I; Papouskova, V; Sklenar, V; Zidek, L; Krasny, L, 2013: The delta Subunit of RNA Polymerase Is Required for Rapid Changes in Gene Expression and Competitive Fitness of the Cell. JOURNAL OF BACTERIOLOGY 195(11), p. 2603 - 2611, doi: 10.1128/JB.00188-13
- Precechtelova, J; Munzarova, ML; Vaara, J; Novotny, J; Dracinsky, M; Sklenar, V, 2013: Toward Reproducing Sequence Trends in Phosphorus Chemical Shifts for Nucleic Acids by MD/DFT Calculations. JOURNAL OF CHEMICAL THEORY AND COMPUTATION 9(3), p. 1641 - 1656, doi: 10.1021/ct300488y
- Papouskova, V; Kaderavek, P; Otrusinova, O; Rabatinova, A; Sanderova, H; Novacek, J; Krasny, L; Sklenar, V; Zidek, L, 2013: Structural Study of the Partially Disordered Full-Length delta Subunit of RNA Polymerase from Bacillus subtilis. CHEMBIOCHEM 14(14), p. 1772 - 1779, doi: 10.1002/cbic.201300226
- Papouskova, V; Novacek, J; Kaderavek, P; Sanderova, H; Rabatinova, A; Zidek, L; Krasny, L; Sklenar, V, 2013: Structural study of partially disordered delta subunit of RNA polymerase unique for gram-positive bacteria. FEBS JOURNAL 280, p. 146 - 147
- Tousek, J; Straka, M; Sklenar, V; Marek, R, 2013: Origin of the Conformational Modulation of the C-13 NMR Chemical Shift of Methoxy Groups in Aromatic Natural Compounds. JOURNAL OF PHYSICAL CHEMISTRY A 117(3), p. 661 - 669, doi: 10.1021/jp310470f
- Novacek, J; Janda, L; Dopitova, R; Zidek, L; Sklenar, V, 2013: Efficient protocol for backbone and side-chain assignments of large, intrinsically disordered proteins: transient secondary structure analysis of 49.2 kDa microtubule associated protein 2c. JOURNAL OF BIOMOLECULAR NMR 56(4), p. 291 - 301, doi: 10.1007/s10858-013-9761-7
2012
- Novacek, J; Haba, NY; Chill, JH; Zidek, L; Sklenar, V, 2012: 4D Non-uniformly sampled HCBCACON and (1) J(NC alpha)-selective HCBCANCO experiments for the sequential assignment and chemical shift analysis of intrinsically disordered proteins. JOURNAL OF BIOMOLECULAR NMR 53(2), p. 139 - 148, doi: 10.1007/s10858-012-9631-8
- Kadam, SS; Tousek, J; Maier, L; Pipiska, M; Sklenar, V; Marek, R, 2012: Understanding the NMR properties and conformational behavior of indole vs. azaindole group in protoberberines: NICS and NCS analysis. JOURNAL OF MOLECULAR STRUCTURE 1028, p. 31 - 38, doi: 10.1016/j.molstruc.2012.06.034
- Pavlikova, N; Blahova, L; Klan, P; Bathula, SR; Sklenar, V; Giesy, JP; Blaha, L, 2012: Enantioselective effects of alpha-hexachlorocyclohexane (HCH) isomers on androgen receptor activity in vitro. CHEMOSPHERE 86(1), p. 65 - 69, doi: 10.1016/j.chemosphere.2011.08.052
2011
- Novacek, J; Zawadzka-Kazimierczuk, A; Papouskova, V; Zidek, L; Sanderova, H; Krasny, L; Kozminski, W; Sklenar, V, 2011: 5D C-13-detected experiments for backbone assignment of unstructured proteins with a very low signal dispersion. JOURNAL OF BIOMOLECULAR NMR 50(1), p. 1 - 11, doi: 10.1007/s10858-011-9496-2
- Pekarova, B; Klumpler, T; Triskova, O; Horak, J; Jansen, S; Dopitova, R; Borkovcova, P; Papouskova, V; Nejedla, E; Sklenar, V; Marek, J; Zidek, L; Hejatko, J; Janda, L, 2011: Structure and binding specificity of the receiver domain of sensor histidine kinase CKI1 from Arabidopsis thaliana. PLANT JOURNAL 67(5), p. 827 - 839, doi: 10.1111/j.1365-313X.2011.04637.x
- Fiala, R; Spackova, N; Foldynova-Trantirkova, S; Sponer, J; Sklenar, V; Trantirek, L, 2011: NMR Cross-Correlated Relaxation Rates Reveal Ion Coordination Sites in DNA. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 133(35), p. 13790 - 13793, doi: 10.1021/ja202397p
2010
- Kovalova, A; Ledvina, M; Saman, D; Zyka, D; Kubickova, M; Zidek, L; Sklenar, V; Pompach, P; Kavan, D; Bily, J; Vanek, O; Kubinkova, Z; Libigerova, M; Ivanova, L; Antolikova, M; Mrazek, H; Rozbesky, D; Hofbauerova, K; Kren, V; Bezouska, K, 2010: Synthetic N-Acetyl-D-glucosamine Based Fully Branched Tetrasaccharide, a Mimetic of the Endogenous Ligand for CD69, Activates CD69(+) Killer Lymphocytes upon Dimerization via a Hydrophilic Flexible Linker. JOURNAL OF MEDICINAL CHEMISTRY 53(10), p. 4050 - 4065, doi: 10.1021/jm100055b
- Motackova, V; Sanderova, H; Zidek, L; Novacek, J; Padrta, P; Svenkova, A; Korelusova, J; Jonak, J; Krasny, L; Sklenar, V, 2010: Solution structure of the N-terminal domain of Bacillus subtilis delta subunit of RNA polymerase and its classification based on structural homologs. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS 78(7), p. 1807 - 1810, doi: 10.1002/prot.22708
- Precechtelova, J; Novak, P; Munzarova, ML; Kaupp, M; Sklenar, V, 2010: Phosphorus Chemical Shifts in a Nucleic Acid Backbone from Combined Molecular Dynamics and Density Functional Calculations. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 132(48), p. 17139 - 17148, doi: 10.1021/ja104564g
- Motackova, V; Novacek, J; Zawadzka-Kazimierczuk, A; Kazimierczuk, K; Zidek, L; Anderova, HS; Krasny, L; Kozminski, W; Sklenar, V, 2010: Strategy for complete NMR assignment of disordered proteins with highly repetitive sequences based on resolution-enhanced 5D experiments. JOURNAL OF BIOMOLECULAR NMR 48(3), p. 169 - 177, doi: 10.1007/s10858-010-9447-3
- Novak, P; Zidek, L; Motackova, V; Padrta, P; Svenkova, A; Nuzillard, JM; Krasny, L; Sklenar, V, 2010: S3EPY: a Sparky extension for determination of small scalar couplings from spin-state-selective excitation NMR experiments. JOURNAL OF BIOMOLECULAR NMR 46(1 I), p. 191 - 197, doi: 10.1007/s10858-009-9392-1
- Kavan, D; Kubickova, M; Bily, J; Vanek, O; Hofbauerova, K; Mrazek, H; Rozbesky, D; Bojarova, P; Kren, V; Zidek, L; Sklenar, V; Bezouska, K, 2010: Cooperation between Subunits Is Essential for High-Affinity Binding of N-Acetyl-D-hexosamines to Dimeric Soluble and Dimeric Cellular Forms of Human CD69. BIOCHEMISTRY 49(19), p. 4060 - 4067
2009
- MACEK, P., CHMELIK, J., KRIZOVA, I., KADERAVEK, P., ZIDEK, L., WILDOVA, M., HADRAVOVA, R., CHALOUPKOVA, R., PICHOVA, I., RUML, T., RUMLOVA, M., SKLENAR, V., 2009: NMR structure of the N-terminal domain of capsid protein from the Mason-Pfizer monkey virus. JOURNAL OF MOLECULAR BIOLOGY 392(1), p. 100 - 114
- Matejkova, M; Zidkova, J; Zidek, L; Wimmerova, M; Chmelik, J; Sklenar, V, 2009: Investigation of Thermal Denaturation of Barley Nonspecific Lipid Transfer Protein 1 (ns-LTP1b) by Nuclear Magnetic Resonance and Differential Scanning Calorimetry. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 57(18), p. 8444 - 8452
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- iNEXT2 - podpora přípravy projektu, Masarykova univerzita, 2018 - 2019
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